Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/315895974?client_source=feed&format=rss
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Friday, June 28, 2013
PFT: Ex-Brown Walcott pleads not guilty
Getty ImagesIn their zeal to defend the name Redskins against disorganized and scattered opposition that gradually is becoming more organized and less scattered, the NFL team bearing that name has had a tendency to seize in knee-jerk fashion upon anything that supports the position that the name isn?t offensive.
The two primary tactics having entailed citing the various high schools that still use the name (there are fewer all the time) and trumpeting the opinions of Native Americans who have no problem with the name, and who ostensibly would regard as a compliment the greeting, ?What?s up, redskin??
As explained by Dave McKenna in an item published earlier today by Deadspin (yeah, I know that one of the morons who works there recently called me a moron . . . again), a supposed Native American Chief whom the Redskins recently trotted out in support of the name isn?t a Chief, and may not even be a Native American.? But the Redskins, who apparently have chosen to dispense with steps like vetting a guest, put the guy on their in-house web show, described him as a Chief, and had him explain why he supports the name.
And, yes, the guy actually said that Native Americans on the ?reservation? actually great each other with, ?Hey, what?s up, redskin??
Complicating matters for the league is that Commissioner Roger Goodell recently pointed to the same non-Chief-possibly-non-Native-American in a letter to member of Congress defending the ongoing use of the name Redskins.
The full item is worth a read, even though it?s a little lengthy.? Also, it probably should include a disclaimer that the author once triggered a defamation lawsuit from owner Daniel Snyder, which gives McKenna a natural bias.
But the point has been made.? Yet again, the Redskins end up looking bad while trying to make their name look good.
If nothing else, we now know why they?ve hired Frank Luntz.? Then again, maybe they think he?s a Chief, too.
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At the Edge of the Solar System, Voyager 1 Finds a Mystery
NASA
In the 35 years since their launch, the two Voyagers have gone where no man or machine has gone before. They flew past Jupiter, Saturn, Uranus, and Neptune, and now Voyager 1 is on course to become the first man-made object to leave our solar system and enter the interstellar medium?the space between stars. (In 2012, PopMech gave a Breakthrough Award to the Voyager team for pushing the frontiers of space exploration.)
This spring, several news organizations inaccurately reported that Voyager 1 had already left the heliosphere?the bubble of charged particles that encircles the sun and its planets. Voyager scientists quickly corrected the reports, stating that the spacecraft remained inside but had encountered some anomalies. Today, three papers published in (Science) provide a more thorough description of the nature of those anomalies. Voyager 1 is still within the solar system, they say, but it has discovered an unexpected layer in the boundary that separates our solar system from the interstellar medium.
"This is a totally new region, not a region predicted by any of our models," Edward Stone, project scientist on the Voyagers, said in a (Science) podcast.
Scientists determine just where Voyager 1 is by studying what kinds of particles strike the spacecraft. Inside the heliosheath, scientists expect Voyager 1 to be bombarded with lots of energetic particles erupting from the sun. The spacecraft should also be able to sense the direction and intensity of the sun's magnetic field. However, while the spacecraft is still inside the solar system, it shouldn't detect low-energy cosmic rays. These rays bounce around interstellar space but can't penetrate the heliosphere. Once beyond the heliosphere, the spacecraft would sense strong cosmic rays, but no particles, and the direction of the magnetic field would change.
On August 25, 2012, something dramatic happened: Voyager 1 stopped getting hit with particles and started detecting cosmic rays for the first time. But the magnetic field didn't change direction, which is what you'd expect if the spacecraft had left the solar system.
So Voyager 1 appears to be in a strange, unexpected region, and scientists aren't sure why such a strange place exists. But Stone gave one possible explanation: "It must be because somehow the solar magnetic field, which is in a huge spiral around the sun?because the sun rotates as the field is carried out, it wraps it into a huge spiral?that somehow the ends of that spiral have become connected, or at least accessible for particles inside to leave, and particles on the outside to enter. Sort of like a magnetic highway, with things inside streaming out, and particles outside streaming in."
Because it's still within the sun's magnetic field, Voyager 1 has not yet broken through into the interstellar medium. So how long until it finally does? Stone and his team just don't know how wide this new region is or how long it will take to cross. He says it could be a few months or several years for Voyager to clear it completely.
Voyager 1 is currently 11 billion miles away from Earth, or about three times the distance between Earth and Neptune. The little-spacecraft-that-could is expected to keep chugging along until 2025, when it will run out of fuel. Who knows what else it'll discover along the way, in the outer regions of our solar system and beyond. "We still have hopefully a good part of the journey left," Stone says.
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7 Surprising Things You Don't Know About Migraines - Health News ...
Getty Images
June is Migraine Awareness Month, putting the spotlight on the pounding, nausea-producing headaches which afflict some 28 million Americans. While there?s an awful lot we do know about migraines, what you don?t know will surprise you:
1. They?ve been linked to suicide risk
Several studies have now linked migraines with an increased risk for suicide attempts and even completed suicide. The risk may be even higher among people with migraine with aura or the flashes of light and other sensory symptoms that can accompany the headaches. It?s not clear why migraines and suicide are related, but depression and migraine share a similar biology, says Dawn Buse, PhD, a health psychologist with Montefiore Medical Center in New York City. Migraine sufferers need to know that ?they?re not alone. They can get help,? says Buse.
2. Your medication could be making migraines worse
Although drugs are meant to help ease the pain of migraines, in some cases this strategy can backfire?badly. Too-frequent use of migraine medications can result in what?s known as ?medication-overuse headaches? and a quickly spiraling vicious cycle. This type of headache can occur with many different medications, including narcotics, acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs, like ibuprofen) and triptans, a class of drugs used specifically to treat migraines. The solution? Try not to use migraine medication, even over-the-counter varieties, more than twice a week.
3. Lightning and migraine can strike together
A study of migraine sufferers in Ohio and Missouri found that the risk of migraine went up on days when there was lightning nearby compared to days when there wasn?t. And weather-related factors such as barometric pressure and humidity, both of which have been linked with migraines in the past, couldn?t explain all of the elevated risk. The study authors speculated that electromagnetic waves from the lightning could be triggering the headaches or that lightning might increase the production of ozone or fungus spores, either of which might spur a migraine.
4. Migraines are linked to other serious health problems
People with migraines have an elevated risk of stroke and of other cardiovascular problems when compared with the general population. The risk of stroke, in particular, is higher still when the migraine is accompanied by aura and in women aged 35 or over, especially those who use oral contraceptives or who smoke. Researchers aren?t sure why stroke and migraines are linked but, regardless, ?a history of migraine with aura should be considered an important risk marker for stroke,? says Buse.
5. A drop in your stress level can bring on a migraine
If you think that finishing your finals or having that big work presentation out of the way will reduce your chance of a migraine, think again. Research by Buse?s team actually found a 20% higher risk of migraines after someone?s mood changed from sad or nervous to happy or relaxed. These ?let-down? migraines may be caused by a sudden, dramatic drop in hormones. How to reduce the likelihood of being let down in this way? Try to avoid peaks of stress in the first place. If it?s finals week, do some yoga or take copious breaks.
6. Sex can trigger migraines
That?s right. Intense physical exertion, including sexual activity, and sometimes even just arousal can actually cause a migraine. Normally this type of migraine is more common in young or mid-life men and, fortunately, usually goes away as the person ages. One obvious solution is to avoid sexual activity but there are easier ways to prevent the migraines. Some doctors will actually prescribe blood pressure medications known as beta blockers to prevent these migraines. And bear in mind that some research suggests sex can actually ease a migraine.
7. Migraines can blow in with the wind
In addition to humidity and barometric temperature, some people swear that an ill wind lies behind their migraine pain. At least one scientific study backs this up. Researchers in Alberta, Canada found an increased risk of migraine on days preceding chinook winds and on days when the winds exceeded 23 miles an hour. Chinooks are warm winds hailing from the west. Overall, about half of migraine sufferers are sensitive to weather factors such as temperature, humidity and barometric pressure, according to another study.
Read more:
Source: http://news.health.com/2013/06/27/surprising-about-migraines/
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Thursday, June 27, 2013
Marc Rich, 'King of Oil' pardoned by Clinton, dies at 78
By Alice Baghdjian
LUCERNE, Switzerland (Reuters) - Billionaire Marc Rich, who invented modern oil trading and was pardoned by President Bill Clinton over tax evasion, racketeering and busting sanctions with Iran, died on Wednesday in Switzerland aged 78.
Rich fled the Holocaust with his parents for America to become the most successful and controversial trader of his time and a fugitive from U.S. justice, enjoying decades of comfortable privacy at his sprawling Villa Rosa on Lake Lucerne.
Belgian-born Rich, whose trading group eventually became the global commodities powerhouse Glencore Xstrata, died in hospital from a stroke, spokesman Christian Koenig said. He is survived by two daughters and six grandchildren. A third daughter died previously of leukemia.
"He will be brought to Israel for burial," Avner Azulay, managing director of the Marc Rich Foundation, said by telephone. Rich will be buried on Thursday at Kibbutz Einat cemetery near Tel Aviv.
Many of the biggest players in oil and metals trading trace their roots back to the swashbuckling Rich, whose triumph in the 1970s was to pioneer a spot market for crude oil, wresting business away from the world's big oil groups.
To his critics he was a white-collar criminal, a serial sanctions breaker, whom they accused of building a fortune trading with revolutionary Iran, Muammar Gaddafi's Libya, apartheid-era South Africa, Nicolae Ceausescu's Romania, Fidel Castro's Cuba and Augusto Pinochet's Chile.
In interviews with journalist Daniel Ammann for his biography, "The King of Oil," the normally secretive Rich admitted to bribing officials in countries such as Nigeria and to assisting the Israeli intelligence agency, Mossad.
Explaining Rich's route to riches in an interview with Reuters in 2010, Ammann said: "He was faster and more aggressive than his competitors. He was able to recognize trends and seize opportunities before other traders. And he went where others feared to tread - geographically and morally."
A U.S. government website once described Rich more simply, as "a white male, 177 centimeters in height ... wanted by the Federal Bureau of Investigation, the U.S. Customs Service and the U.S. Marshall Service." In 1983, he was on the FBI's 10-most-wanted list indicted for tax evasion, fraud and racketeering. At the time, it was the biggest tax-evasion case in U.S. history.
FLED POSSIBLE LIFE SENTENCE
Rich, who valued trust, loyalty, secrecy and persistence, always insisted he did nothing illegal and among those who lobbied Clinton on his behalf for his pardon were former Israeli Prime Ministers Ehud Barak and Shimon Peres.
On learning of the indictment plans, Rich fled to Switzerland to escape the charges, which included exploiting the U.S. embargo against Iran, while it was holding U.S. hostages, to make huge profits on illicit Iranian oil sales.
"Marc Rich is to asset concealment what Babe Ruth was to baseball," said Arthur J. Roth, New York state commissioner of taxation and finance.
He remained under threat of a life sentence in a U.S. jail until Clinton pardoned him during the last chaotic hours of his presidency, a move that provoked moral outrage and bewilderment among some politicians. He never returned to the United States.
Rich's ex-wife, Denise, had donated funds for Clinton's presidential library. The former president later said the donation was not a factor in his decision and he had acted partly in response to a request from Israel. He regretted granting the pardon, calling it "terrible politics."
"It wasn't worth the damage to my reputation," he told Newsweek magazine in 2002.
There was also scrutiny over the role of Eric Holder, now the attorney general and then a deputy attorney general who recommended the pardon.
Rudolph Giuliani, who had worked as a prosecutor on the Rich case before becoming New York Mayor, said in a statement: "Mark Rich committed serious crimes against the United States and then fled the country when he was called to account for his conduct. He should never have been pardoned."
"The fact that Bill Clinton and Eric Holder engineered a pardon for him - without input from me, as the U.S. Attorney who prosecuted him, or Janet Reno, as Attorney General, will forever be a blemish on our justice system," Giuliani said.
'ARTISTRY OF A POOL SHARK'
In one biography, "Metal Men: Marc Rich and the 10-Billion-Dollar Scam," author A. Craig Copetas described Rich as "a beautifully sinister executive who could frame deals with the artistry of a pool shark."
Rich inherited his business acumen from his father, who became a millionaire by setting up an agricultural trading firm after emigrating to the United States.
Born Marcell David Reich in Antwerp on December 18, 1934, Rich started his career at Philipp Brothers, a top global commodities trader after World War Two.
Posted to Madrid in the late 1960s, he found ways to bypass the "Seven Sisters" major oil companies that controlled world oil supplies. Rich was one of the first to loosen their grip, becoming a middle man who bought cargoes of oil from one company to sell to another on a short-term basis, helping give birth to the dynamic market that exists today.
While at Phibro, Rich foresaw the huge price increases imposed by the Organisation of Petroleum Exporting Countries in 1973, earning big profits for the firm.
Infuriated by his pay and trading strictures, he left in 1974 along with a fellow graduate of the Phibro mailroom, Pincus "Pinky" Green, and set up Marc Rich and Co AG in Switzerland, a firm that would eventually become Glencore Xstrata Plc.
ANGER AND AMBITION
His aim, according to Copetas, was "to grind Philipp Bros. into oblivion," and he poured all his anger and ambition as well as his charm and gracious client demeanor into the new venture.
It became a highly successful trading firm and a much feared adversary in energy, metals, minerals, grains and sugar markets.
Thomas Gloor worked for Marc Rich for about seven years, starting out in the finance department straight from university and moving to trade futures and options before growing disillusioned with the firm and leaving in 1986.
"Ethics didn't really matter to them. They would trade anything with anyone ... It was all about just making more and more money," he said.
Rich later sold that company, which became Glencore International AG, and set up the Marc Rich Group. Rich was known for charitable donations through his Doron Foundation to Zurich's Jewish community.
Glencore Xstrata Chief Executive Ivan Glasenberg said: "He was a friend and one of the great pioneers of the commodities trading industry, founding the company that became Glencore."
As well as his villa on the Swiss lake, Rich maintained houses in Marbella in Spain and in Israel.
Rich described himself as a keen tennis player, skier, alpinist and patron of the arts. Those who knew him said in private Rich was calm and charming with a sense of humor.
In later years, Rich's fortune dwindled after his property portfolio was hit by the Spanish housing crisis.
"I invested a lot of money there and because of the crisis also lost a lot, at least on paper," he told Swiss economic magazine Bilanz. Forbes put his wealth at $2.5 billion.
He also invested with Bernard Madoff, the financier later convicted of operating a huge pyramid scheme. Rich told one magazine that he had had a "strange feeling" about the investment and "got out with everything," although he said he lost some money through "indirect participation".
Rich once told Fortune magazine he was a normal person with an image problem. "I've been portrayed in a horrible way," he said, "as a workaholic, a loner, a money machine. It's not a true picture."
Nevertheless, to his enemies he remained a symbol of the monomaniacal pursuit of vast wealth.
"The smoking gun is greed," said Ken Hill, a U.S. Marshall who hunted Rich around the world for more than a decade. "This is what Marc thrived on - the greed of those who had commodities and were in positions of influence and power."
Those who knew him say Rich never lost his appetite for a deal. He traveled to London earlier this month and had a dinner with several old friends, an old acquaintance told Reuters.
"He was doing well. He told me he was doing a little bit of business. 'I enjoy doing business,' he said."
(Additional reporting by David Brunnstrom, Ron Bousso, Caroline Copley, Emma Thomasson, Clara Ferreira-Marques, Dmitry Zhdannikov, Emma Farge, Tom Miles, Josephine Mason and David Sheppard; Writing by Peter Millership; Editing by Philippa Fletcher, Peter Graff and Prudence Crowther)
Source: http://news.yahoo.com/marc-rich-king-oil-pardoned-clinton-dies-78-210459269.html
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Humans play role in Australia's 'angry' hot summer
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Wednesday, June 26, 2013
Mass. voters head to polls to pick new US senator
This panel of May 2013 file photos shows Republican Gabriel Gomez, left, and Democrat U.S. Rep. Ed Markey, right, candidates for U.S. Senate in the June 25, 2013 special election, being held to fill the seat vacated when John Kerry was appointed as secretary of state. (AP Photos/File)
This panel of May 2013 file photos shows Republican Gabriel Gomez, left, and Democrat U.S. Rep. Ed Markey, right, candidates for U.S. Senate in the June 25, 2013 special election, being held to fill the seat vacated when John Kerry was appointed as secretary of state. (AP Photos/File)
Massachusetts Senate Democratic candidate Ed Markey, left, meets and greets grassroots volunteers and supporters at the Pickle Barrel Restaurant & Deli, in Worcester, Mass., Monday, June 24, 2013. Markey and Republican Gabriel Gomez made appeals to voters Monday in the final hours before Massachusetts' special election for the U.S. Senate, where turnout is expected to be light, a contrast to the high-profile special election in the state three years ago. (AP Photo/Worcester Telegram & Gazette, John Ferrarone)
Gabriel Gomez, Republican candidate for U.S. Senate in the Massachusetts open seat special election, greets supporters, Monday, June 24, 2013, at the Four Square restaurant in Braintree, Mass. Gomez faces Democrat Rep. Ed Markey in Tuesday's election. (AP Photo/Josh Reynolds)
Massachusetts Senate Democratic candidate Ed Markey, right, meets and greets grassroots volunteers and supporters at the Pickle Barrel Restaurant & Deli, in Worcester, Mass., Monday, June 24, 2013. Markey and Republican Gabriel Gomez made appeals to voters Monday in the final hours before Massachusetts' special election for the U.S. Senate, where turnout is expected to be light, a contrast to the high-profile special election in the state three years ago. (AP Photo/Worcester Telegram & Gazette, John Ferrarone)
Gabriel Gomez, Republican candidate for U.S. Senate in the Massachusetts open seat special election, greets supporters, Monday, June 24, 2013, at the Four Square restaurant in Braintree, Mass. Gomez faces Democrat Rep. Ed Markey in Tuesday's election. (AP Photo/Josh Reynolds)
BOSTON (AP) ? Democratic U.S. Rep. Edward Markey and Republican Gabriel Gomez scrambled to energize supporters and mobilize get-out-the-vote efforts in Massachusetts in the hours leading up to Tuesday's special election to succeed John Kerry in the U.S. Senate.
Both candidates made a series of campaign stops Monday, culminating with election eve rallies, while their campaigns cranked up their all-important ground games designed to get as many of their voters to the polls as possible on a day when statewide turnout was expected to be light.
Gomez voted Tuesday morning in Cohasset, where he lives with his wife and four children.
He said he was humbled and proud of the opportunity to vote for himself, saying the election was about choosing the future over the past and what he called Markey's failure to take on the important issues, despite 37 years in office.
"You know, where I come from that is mission incomplete," said the former Navy SEAL, adding he was asking for just 17 months, the remainder of Kerry's term.
"Give me a chance to go down there for 17 months and accomplish the mission, which I've done all my life," Gomez said.
Markey, 66, was scheduled to vote later Tuesday in his hometown of Malden. He has led in the polls but said he's taking nothing for granted.
"There is no overconfidence in this entire operation," Markey told reporters after an evening rally in Malden.
The longtime Democratic member of the Massachusetts U.S. House delegation explained that his campaign has called or rang the doorbells of 3 million prospective voters in the last four days.
"That's the sign of an organization working hard right up to the finish line," he added.
Gomez, 47, is a political newcomer and former Navy SEAL who worked for a Boston-based private equity firm before jumping into the race.
Gomez was also urging his supporters to get themselves to the polls and to remind their friends and family members to vote, too.
"Tell your friends. Tell your friends to tell their friends they need to vote," Gomez said at an evening rally in Quincy with former GOP U.S. Sen. Scott Brown.
"They think there's going to be a low turnout. There may be a low turnout on their side. That's fine with me. But I know our side and it's a broad side," he added.
Massachusetts state Secretary William Galvin said Monday he expected a lackluster turnout on Tuesday, with no more than 1.6 million of the state's 4.3 million registered voters to cast ballots in the special election, well below the 2.2 million who voted in a 2010 special election, won by Brown, to succeed the late Sen. Edward Kennedy.
Based on a number of factors, including absentee ballots and the relatively few inquiries to his office about the election, the current race was not matching the intensity of the 2010 election, Galvin said.
Markey has held a fundraising advantage throughout the campaign, having spent more $8.6 million on the race through the end of the last reporting period on June 5, compared with $2.3 million by Gomez, according to Federal Election Commission records.
Also on the ballot Tuesday is Richard Heos, who is affiliated with the Twelve Visions Party.
Polls are open until 8 p.m.
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Series of bomb attacks in Iraq kill at least 42
BAGHDAD (AP) ? A series of evening bombings near markets in and around Baghdad and other blasts north of the capital killed at least 42 people and wounded dozens of others Monday in the latest eruption of bloodshed to rock Iraq.
The attacks were the latest in a wave of violence that has claimed more than 2,000 lives since the beginning of April. Militants, building on Sunni discontent with the Shiite-led government, appear to be growing stronger in central and northern Iraq.
The violence came as tens of thousands of Shiites poured into the holy city of Karbala, 80 kilometers (50 miles) south of Baghdad, for the annual festival of Shabaniyah, marking the anniversary of the birth of the ninth-century Shiite leader known as the Hidden Imam. Tight security measures were in force to try to prevent insurgent attacks on the worshippers.
One of the deadliest attacks came at night when two bombs placed near a market blew up less than a minute apart in Baghdad's mostly Shiite neighborhood of Husseiniyah, killing ten people and wounding 30 others.
Police said the second bomb went off among a group of people who had gathered at the scene to help the victims of the first blast.
Bassem Hazim, a merchant from Husseiniyah, said he was preparing for night prayers when he heard an explosion. He went out to see what happened.
"As we came near the blast site, a second bomb went off in the crowd. We helped carry some wounded people to the hospital. All the shops closed and all the shoppers fled, he said, but "government officials are busy with trips abroad and contracts while the country is bleeding."
Earlier, police said that two car bombs exploded within minutes on a commercial street in the mixed neighborhood of Jihad in western Baghdad, killing nine people and wounding 21 others, police said.
Also, four people were killed and nine others were wounded when a car bomb exploded near a line of shops in the Shiite-dominated area of al-Shurta al-Rabeaa.
Interior Ministry spokesman Saad Maan Ibrahim said that al-Qaida is avoiding direct confrontation with the security forces and instead are choosing civilian targets.
"By attacking soft targets like markets, al-Qaida wants to send a message that they are still active and still capable of striking anywhere in Iraq," he said.
Police said car bomb exploded near a supermarket on a main commercial street in the Shiite Karrada neighborhood, killing five people and wounding 16.
Just after sunset, police said a car bomb went off near an outdoor market in the Shiite suburb of Nahrawan, killing four civilians and wounding 15 others.
Minutes later, a car bomb went off near a market in the Shiite-majority neighborhood of New Baghdad. Police said that three people were killed and 10 others were wounded. Minutes later, a second car bomb hit a bus stop in the same neighborhood, killing two people and wounding eight others.
Also, two people were killed in a car explosion in the Christian-Shiite neighborhood of Garage al-Amana in southeastern Baghdad.
In the morning, a provincial police officer in Ninevah said a suicide attacker rammed his explosives-laden car into an army patrol in the city of Mosul, killing a soldier and a police officer. He said that seven people, including two civilians, were wounded. Mosul is 360 kilometers (220 miles) northwest of Baghdad.
Another officer said a second bomber blew set off his explosive-rigged belt inside a university campus in the city of Tikrit, killing a police officer. The city is 130 kilometers (80 miles) north of Baghdad.
Two medical officials confirmed casualty figures. All spoke anonymously as they were not authorized to release information to reporters.
There was no immediate claim of responsibility, but security forces and Shiite residents are frequently targeted by al-Qaida's Iraq branch.
___
Associated Press writer Qassim Abdul-Zahra contributed to this report.
Source: http://news.yahoo.com/series-bomb-attacks-iraq-kill-least-42-193647756.html
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New screening approach quickly identifies small proteins unique to melanoma cells
June 25, 2013 ? Jamie K. Teer, Ph.D., assistant member of the Cancer Biology and Evolution Program at Moffitt Cancer Center, and colleagues have developed a new streamlined method to rapidly identify the genetic changes in small protein fragments unique to melanoma cancer cells. These fragments can be used as targets for tumor-infiltrating lymphocytes that have been shown to reduce cancerous lesions.
The new approach is outlined in an article published online by Nature Medicine in May.
A previous phase 2 clinical trial showed substantial regression of metastatic lesions in up to 70 percent of melanoma patients who were treated with self-donated tumor-infiltrating lymphocytes.
"The trial, which involved the adaptive transfer of a patient's own immune cells, showed a complete tumor regression lasting at least five years in nearly 40 percent of the patients," Teer said. "To better understand how this works, researchers needed to identify tumor-infiltrating lymphocytes. We developed a new method to help do that more quickly."
Tumor-infiltrating lymphocytes are white blood cells that have left the bloodstream and migrated into a tumor. When numerous tumor-infiltrating lymphocytes are present, it suggests an immune response against the tumor. Research into quantifying the tumor-infiltrating lymphocytes and relating those numbers to tumor characteristics and outcomes has been carried out across many types of cancer.
According to Teer, a better understanding of how tumor-infiltrating lymphocytes induce cancer cell regression should increase the effectiveness of patient-donated cell therapy and also potentially reveal novel mechanisms of tumor growth. The technique uses next-generation DNA sequencing technologies to identify the changes that lead to the unique protein fragments.
"Our new technique allowed us to more quickly and easily identify mutated gene antigens recognized by T-cells in the immune system," explained Teer. "Work such as this was previously done by generating and laboriously screening DNA libraries from tumors. The same screening technique may be applicable for identifying mutated antigens in a variety of tumor types."
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The above story is reprinted from materials provided by Moffitt Cancer Center.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal Reference:
- Paul F Robbins, Yong-Chen Lu, Mona El-Gamil, Yong F Li, Colin Gross, Jared Gartner, Jimmy C Lin, Jamie K Teer, Paul Cliften, Eric Tycksen, Yardena Samuels, Steven A Rosenberg. Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells. Nature Medicine, 2013; 19 (6): 747 DOI: 10.1038/nm.3161
Note: If no author is given, the source is cited instead.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/mtRajRWdFd4/130625120927.htm
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Saturday, June 15, 2013
Video: Can 'Man of Steel' Fly
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Source: http://www.nbcnews.com/video/cnbc/52209408/
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Key issues facing Iran
The following are the main domestic and international issues facing Iran's incoming president, Hasan Rowhani:
___
NUCLEAR QUESTION: Four rounds of revived talks between Iran and world powers since last year have produced no important headway in Tehran's impasse with the West. The U.S. and allies worry Iran's uranium enrichment could lead to atomic weapons, which could shift the balance of power in the region and give allies such as Lebanon's Hezbollah access to nuclear material. Iran denies it seeks nuclear arms, often citing a religious edict by Supreme Leader Ayatollah Ali Khamenei rejecting such weapons and saying it only seeks nuclear reactors for energy and medical applications. But it refuses to consider giving up any part of the "nuclear cycle," which includes processing and enriching uranium. Israel has said it keeps options open to attack Iran's nuclear sites, but Washington and other Western allies appear committed for now to a combination of diplomacy and economic sanctions to pressure Tehran.
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SANCTIONS: International sanctions led by the U.S. and European Union have sharply increased in recent years, targeting Iran's vital oil exports and limiting its access to global financial networks for trade payments. Oil sales ? Iran's main foreign currency source ? have been cut by more than half, although shipments still go to major Asian markets such as China and India under U.S. waivers. On July 1, the U.S. could put in motion tighter sanctions seeking to limit gold sales to Iran, which have become a critical financial lifeline. Much of the gold trade has flowed through U.S. allies Turkey and the United Arab Emirates. Iranian leaders claim they can ride out sanctions through a "resistance economy" that encourages domestic manufacturing and sale of refined petroleum products, which are not covered by sanctions.
___
ECONOMY: Iran's economy has been locked in a downward spiral from a mix of sanctions and domestic fiscal mismanagement, blamed on outgoing President Mahmoud Ahmadinejad's policies of subsidies and handouts. The national currency, the rial, has plummeted in value from about 10,000 to the U.S. dollar two years ago to just under 35,000. This has driven up inflation, with prices for some goods tripling. Unemployment is officially at 13 percent, but most economists believe it could be more than twice that figure.
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OPPOSITION: Years of widespread crackdowns have left the opposition movement shattered and without a guiding hand. Authorities have placed under house arrest the leaders of the protest movement after Ahmadinejad's disputed 2009 re-election. No serious attempts have been made to mobilize street demonstrations since early 2010. In the intervening years, Iran's Revolutionary Guard has grown in power and expanded its networks, including paramilitary groups known as the Basij corps that are present in nearly every town or neighborhood around the country.
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U.S. RELATIONS: Despite hopes for a breakthrough after President Barack Obama's election in 2008, no significant progress has been made to end the more than three-decade diplomatic freeze. Iranian and U.S. envoys have had contact during nuclear talks, and the two countries found a common cause earlier this year to keep wrestling on the 2020 Olympic program after the International Olympic Committee dropped the sport from its core program. Many of the Iranian presidential candidates, Rowhani included, had suggested the possibility of a less antagonistic relationship with Washington, but any such decision rests with the supreme leader.
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REGIONAL ROLE: The future of Syrian President Bashar Assad is a pivotal issue for Iran. Without Assad, Iran stands to lose its main Arab ally in the region. It also could cut the easy supply lines to Iranian proxy Hezbollah in Lebanon. But in other areas, Tehran has deepened crucial ties. Iran's influence spills out from both sides of its borders into Iraq and Afghanistan. It also has embarked on a military buildup to challenge U.S. and Gulf Arab forces. Iran has announced a series of purported advances, including drones and a fighter jet, but military analysts question the authenticity of some of the claims.
Source: http://news.yahoo.com/key-issues-facing-iran-081539967.html
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WhatsApp Still Killing It By Messaging Volume Despite Free Rivals Crowding In
Along with Skype, WhatsApp is the granddaddy of the mobile messaging app space. But despite its relative great age it appears to be continuing to build usage momentum. Earlier today WhatsApp announced a new daily messaging metric record, following on from its recent "bigger than Twitter" boast. Its new daily high is 10 billion+ inbound (sent) messages and 17 billion+ outbound (received) messages.Source: http://feedproxy.google.com/~r/Techcrunch/~3/8X60up-TDc8/
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Tuesday, June 11, 2013
Sewing Craft Information: Leisure Time Hobbies for Women
As many women get to the age where they are opting to become stay at home mom, or their children are growing to an age in which they do not need the regular supervision that was once required, women are being faced with an almost extravagant amount of free time and no real understanding of how this time could and should be spent. While it is true that you can opt to clean the house on a regular basis, not only is this task going to become boring and methodical, but it is not going to help you grow and build on your capabilities as a woman and a human being.
More...Source: http://sewingcraftblog.blogspot.com/2013/06/leisure-time-hobbies-for-women.html
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Erdogan calls Turkish protesters 'those who burn and destroy'
Turkey's Prime Minister?Recep Tayyip?Erdogan has visited several cities to verbally challenge the mass demonstrations against his rule.
Turkish Prime Minister Recep Erdogan arrives in Ankara on Sunday.
Vadim Ghirda/AP
EnlargeIn a series of increasingly belligerent speeches to cheering supporters Sunday, Turkey's prime minister launched a verbal attack on the tens of thousands of anti-government protesters who flooded the streets for a 10th day, accusing them of creating an environment of terror.
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Recep Tayyip?Erdogan?made the most inflammatory of his speeches as he arrived in the capital, Ankara. Erdogan?belittled the protesters, again calling them "capulcu," the Turkish word for looters or vandals. He made his speech in Ankara on an open-top bus, which then drove into the city in a motorcade.
"If you look in the dictionary, you will see how right a description this is,"?Erdogan?said, speaking to thousands of supporters who greeted him at the airport. "Those who burn and destroy are called capulcu. Those who back them are of the same family."
The increasingly fiery tone could inflame tensions, with protesters in both Ankara and the country's largest city, Istanbul, remaining on the streets. Protests have been held in at least 78 cities across the country so far. On two occasions, including one in the southern city of Adana Saturday night, clashes have been reported between?Erdogan?supporters and protesters.
"All they do is to break and destroy, to attack public buildings ... They didn't stop at that,"?Erdogan?said. "They attacked daughters who wear headscarves. They entered Dolmabahce mosque with their beer bottles and their shoes."
Beer in mosque denied
Some of the injured in the initial clashes in Istanbul's Besiktas area were treated in Dolmabahce mosque. The mosque's imam has denied reports that people entered with beer. In the initial days of the protests, some women said they were harassed verbally. The majority of protesters however, have denounced those who did it and have been welcoming toward them.
Anti-government protesters have turned?Erdogan's?label of them as "capulcu" into a humorous retort, printing stickers with the word, scrawling it on their tents, and uploading music videos onto social network sites.
Erdogan?had earlier visited another two cities where unrest had occurred and made speeches again condemning his detractors. He planned more speeches in a day that looked much like an election candidate on the campaign trail.
After the speech, crowds at Istanbul's Taksim Square swelled, with several tens of thousands packing into the square. Thousands more flooded Ankara's central square, a day after police used tear gas and water cannons to oust them from the area.
Erdogan's?refusal to moderate his tone caused dismay.
"As the prime minister continues [with] his harsh style, the resistance also continues and is getting bigger," said Cagdas Ersoy, a 23-year-old student who joined the protests in Ankara's Kizilay square. "He is making the resistance bigger without realizing it."
Protester Cihan Akburun said: "He should not provoke the people. We invite everyone to [have] common sense."
Erdogan points to election wins
Erdogan?challenged the protesters at the ballot box.
"It's not these marginal groups, but the people, who are going to call us to account, and they are going to do it at the ballot box. The people brought us here [through elections] and it's the people who will vote us out. Apart from the people, no one has the power to oust us," he said.
"Stand firm, don't yield, Turkey is with you," his supporters chanted in return.
The nationwide anti-government protests were sparked by outrage over police use of force against an environmental protest in Istanbul's Taksim Square on May 31, and have grown into a display of discontent toward?Erdogan's?government.
The protests have attracted a diverse crowd from a variety of social backgrounds and age groups. Many accuse the prime minister of becoming increasingly authoritarian after 10 years in power and of trying to impose his conservative, religious mores in the country which is governed by secular laws.
Erdogan?has rejected the accusations, insisting he respects all lifestyles and is the "servant" of his people.
Three people have died in the protests, including a police officer in Adana who fell into an underpass that was under construction while chasing demonstrators. More than 4,300 protesters have sought medical treatment, human rights groups have said.
Shopping mall shelved
Thousands of protesters have occupied Taksim and its Gezi Park, where the protests began over objections to Erdogan's?plan to develop the park by building a replica Ottoman barracks and a shopping mall. The mall idea has since been dropped, and has been replaced by possibilities of an opera house, theater, and museum.
Erdogan, referring to the crowd of thousands of supporters before him, said: "The whole of Turkey should look at Ankara. They should not look at those who are wreaking terrorism."
He again made obscure references to an "interest rates lobby" as being involved in the protests, saying that they would be made to account "heavily." For those who might speculate on the financial markets, he said: "If we catch you speculating, we will strangle you."
The prime minister accused the anti-government protesters of killing policemen and said hundreds of police had been injured. So far, only one police death has been confirmed officially ??that of the officer who fell into the underpass.
Earlier in the day, he gave a speech in Adana, where pro- and anti-government protesters clashed Saturday night, according to the state-run Anadolu Agency.
"We won't do what a handful of looters have done. They burn and destroy.... They destroy the shops of civilians. They destroy the cars of civilians," he told supporters at Adana airport. "They are low enough to insult the prime minister of this country."
He urged his supporters to avoid violence themselves and predicted that his Islamic-rooted party would defeat his opponents during local elections in March.
"I want you to give them the first lesson through democratic means in the ballot box," he said.
Erdogan?has repeatedly branded the protests as illegal efforts to discredit his government before local elections next year. He frequently refers to the 50 percent majority he received in elections in 2011 to dismiss the protest as attempts by a minority group to dominate over a majority of his supporters.
* Elena Becatoros reported from Istanbul.
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Monday, June 10, 2013
The Krotocam is a DIY Steadicam You Can Build On the Cheap
Nothing beats a Steadicam for capturing smooth video, but the commercially-available models can run for hundreds or thousands of dollars. But if you're willing to do a little work, you can build your own for small camcorders and dSLRs for about $30-40.
The video above from Krotoflik walks you through the entire process. Most of the parts you need won't be lying around your house, but they aren't too hard to find online. A collection of washers at the base serves as a customizable counterweight to keep your rig balanced, while a dollar store flashlight is used as a clever free-rotating gymbal. The finished product looks surprisingly professional, and the sample footage linked at the end of the video is very impressive for something so inexpensive.
If you love this idea, but want something a little more compact for a GoPro camera, Krotoflik also offers a modified tutorial for the Krotocam Mini. Whichever model you choose, the video you capture should be leaps and bounds smoother than anything you could get by shooting handheld.
How to Build the Krotocam (DIY Steadicam) | YouTube via DIY Photography
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