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Thursday, May 3, 2012
Justin Bieber's Best Real-Life 'Boyfriend' Moments
Bieber is bringing his 'Boyfriend' video to MTV on Thursday at 7:50 p.m., followed by a live Q&A on MTV.com!
By Jocelyn Vena
<P><a href="http://www.mtv.com/music/artist/bieber_justin/artist.jhtml">Justin Bieber</a>'s <a href="/news/articles/1684156/justin-bieber-boyfriend-music-video-premiere-thursday.jhtml">"Boyfriend" video</a>, premiering Thursday on "MTV First," is going to have to be pretty over-the-top to compete with Bieber's real-life boyfriend skills. </P><P> </P><P>After all, he has a <a href="/news/articles/1682957/justin-bieber-boyfriend-tips.jhtml">stringent set of rules</a> when it comes to being the perfect boyfriend to fellow superstar <a href="http://www.mtv.com/music/artist/gomez__selena/artist.jhtml">Selena Gomez</a>. During their year-plus relationship, Justin has swept Selena off her feet with some pretty elaborate dates. </P><P> </P><P><center><embed src="http://media.mtvnservices.com/mgid:uma:video:mtv.com:757423/cp~vid%3D757423%26uri%3Dmgid%3Auma%3Avideo%3Amtv.com%3A757423" width="460" height="260" type="application/x-shockwave-flash" allowFullScreen="true" allowScriptAccess="always" base="."></embed></center> </P><P> </P><P>In anticipation of Thursday's "Boyfriend" premiere, MTV News is rounding up the five best dates Bieber has taken Selena on. In the words of Bieber, #leggo! </P><P> </P><P><big><b>St. Lucia</b></big><br> </P><P>In January 2011, the couple were snapped on <a href="/news/articles/1655145/justin-bieber-selena-gomez-spotted-together-in-st-lucia.jhtml">vacation in St. Lucia</a>. The vacation was headline-making simply because it was the first major sighting of the couple being romantic. Although they had been rumored to be dating weeks before, the paparazzi shots confirmed to the world that Jelena were alive and well. </P><P> </P><P><big><b>2011 Oscars</b></big><br> </P><P>In February of that year, the couple were shy no more about their relationship. They graced the <a href="/news/articles/1658832/justin-bieber-selena-gomez-vanity-fair-oscars.jhtml"><i>Vanity Fair</i> Oscar party</a> that year together, walking the carpet arm-in-arm with big smiles. </P><P> </P><P><big><b>2011 VMAs</b></big><br> </P><P>Later in the year at the <a href="/news/articles/1669881/vmas-justin-bieber-selena-gomez.jhtml">VMAs</a>, while Gomez was on hand helping MTV News out as the pre-show co-host, Bieber surprised his lady love with a very public kiss on the cheek and his pet snake, Johnson. </P><P> </P><P><big><b>Staples Center</b></big><br> </P><P>What better way to <a href="/news/articles/1671462/justin-bieber-selena-gomez-staples-center.jhtml">watch "Titanic"</a> than by renting out the entire Staples Center in Los Angeles? After checking out Demi Lovato's show at the Nokia Theatre in September 2011, he went right across the street with Gomez to watch the flick in private. </P><P> </P><P><big><b>Movie Theater</b></big><br> </P><P>The private Staples screening must have worked, because weeks later, Bieber rented out a theater in Canada to <a href="/news/articles/1672989/justin-bieber-selena-gomez-real-steel-private-screening.jhtml">check out the less-romantic "Real Steel."</a> </P><P> </P><P><big><b>Lakers Game</b></big><br> </P><P>Earlier this month, when the young couple hit up a Lakers game at the Staples Center, they were caught kissing on the famous <a href=" http://www.mtv.com/photos/spotted-daily-celebrity-sightings/1617615/7079058/photo.jhtml">Kiss Cam</a>. Can you remember who won the game between the Lakers and San Antonio Spurs? Nope, because the couple's PDA made more headlines. </P><P> </P><P>Not enough Bieber for you? Well, the singer will sit down with MTV News' Sway Calloway on Thursday to premiere his "Boyfriend" music video during "MTV First: Justin Bieber" live at 7:50 p.m. ET on MTV. After the video premieres on air, Bieber will chat with Sway for 30 minutes on MTV.com, opening up about the Director X-directed clip, as well as his June 19 album release, <i>Believe.</i> But that's not all: If you have a burning question for Bieber, you can get in on the fun by commenting below or tweeting @MTVNews with the hashtag #MTVFirst or #AskBieber. </P><P> </P><P>Immediately following the premiere, the "Boyfriend" video will be available on MTV.com, so Beliebers can watch it over and over and over again. </P><P> </P><P><b>Don't miss the "Boyfriend" video premiere Thursday, May 3, at 7:50 p.m. ET/PT on MTV during "MTV First: Justin Bieber," followed by a live Q&A with Justin himself on MTV.com!</b> </P><P> </P><P><a href="http://www.mtv.com/photos/?fid=1617615"><img src="http://www.mtv.com/news/photos/s/spotted/banner/spotted.jpg"></a></p>
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WATCH: Eva Mendes Is a Single Mom in 'Girl in Progress'
In real life, Eva Mendes is enjoying a red-hot acting career and a budding romance with the most lusted-after man in Hollywood (a.k.a. Ryan Gosling). Her character in the upcoming dramedy Girl in Progress (in theaters May 11 -- just in time for Mother's Day) isn't quite so lucky. Mendes' Grace is a single mother who is so preoccupied juggling two jobs and an affair with a very married man (Matthew Modine) that she doesn't have the time to give her 13-year-old daughter Ansiedad (Cierra Ramirez) the attention she needs.
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Wednesday, May 2, 2012
Molecular spectroscopy tracks living mammalian cells in real time as they differentiate
Molecular spectroscopy tracks living mammalian cells in real time as they differentiate
Monday, April 30, 2012Knowing how a living cell works means knowing how the chemistry inside the cell changes as the functions of the cell change. Protein phosphorylation, for example, controls everything from cell proliferation to differentiation to metabolism to signaling, and even programmed cell death (apoptosis), in cells from bacteria to humans. It's a chemical process that has long been intensively studied, not least in hopes of treating or eliminating a wide range of diseases. But until now the close-up view ? watching phosphorylation at work on the molecular level as individual cells change over time ? has been impossible without damaging the cells or interfering with the very processes that are being examined.
"To look into phosphorylation, researchers have labeled specific phosphorylated proteins with antibodies that carry fluorescent dyes," says Hoi-Ying Holman of the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab). "That gives you a great image, but you have to know exactly what to label before you can even begin."
Holman and her coworkers worked with colleagues from the San Diego and Berkeley campuses of the University of California to develop a new technique for monitoring protein phosphorylation inside single living cells, tracking them over a week's time as they underwent a series of major changes.
"Now we can follow cellular chemical changes without preconceived notions of what they might be," says Holman, a pioneer in infrared (IR) studies of living cells who is director of the Berkeley Synchrotron Infrared Structural Biology program at Berkeley Lab's Advanced Light Source (ALS) and head of the Chemical Ecology Research group in the Earth Sciences Division. "We've monitored unlabeled living cells by studying the nonperturbing absorption of a wide spectrum of bright synchrotron infrared radiation from the ALS."
The researchers report their results in the journal Analytical Chemistry.
Phosphorylation fundamentals
Phosphorylating enzymes add one or more phosphate groups to three amino-acid residues common in proteins ? serine, threonine, or tyrosine ? which activates the proteins; removing the phosphate reverses the process. The research goal is to learn exactly when proteins such as enzymes and receptors are switched on and off by phosphorylation, and which cells within a population respond to cause specific changes ? for example, during differentiation of a progenitor cell into its functional form.
To avoid killing cells or introducing modified proteins or foreign bodies that may alter their behavior, scientists can use a method called Fourier-transform infrared (FTIR) spectromicroscopy; because infrared light has lower photon energy than x-rays, it can peer inside living cells without damaging them. Different components and different states of the cell absorb different wavelengths of the broad infrared spectrum; applying the Fourier-transform algorithm allows signals of all frequencies to be recorded simultaneously, pinpointing when, where, and what different chemical changes are occurring.
Most infrared sources are dim, however, so the information from typical IR set-ups is limited in resolution and has a low signal-to-noise ratio. Infrared from the ALS's synchrotron light source is a hundred to a thousand times brighter.
Previously Holman and her colleagues have used IR beamline 1.4.3, managed by Berkeley Lab's Michael Martin and Hans Bechtel, to obtain spectra from living organisms in rock, soil, and water. They have monitored ongoing biochemistry within living bacteria adapting to stress, and more recently within individual skin connective tissue cells (fibroblasts) from patients with mitochondrial disorders. (Mitochondria are the cellular organelles commonly known as the "power-plants" of the cell.)
The present study was done with a line of cultured cells called PC12. When nerve growth factor, a small protein, is introduced into a PC12 cell, the cell begins to send out neurites resembling the projections from nerve cell bodies. Although originally derived from a tumor of the rat's adrenal gland, PC12 has become, rather counterintuitively, a valuable model of how nerve cells differentiate from their unspecialized progenitors.
Berkeley Lab postdoctoral fellow Liang Chen began the current experiments by introducing nerve growth factor to groups of PC12 cells to induce them to differentiate; one group of cells was left untreated as a control. The cells were cultured on gold-coated slides in chambers maintained at body temperature in a humidified environment and supplied with nutrients. Individual cells of a group were positioned under the infrared beam at the beamline 1.4.3 endstation.
FTIR spectra were collected before and after the nerve growth factor was introduced. After stimulation, the spectra were taken first at short intervals, from two to sixty minutes apart. Additional spectra were collected of cells in other groups on the third, fifth, and seventh day of continued stimulation.
The first day's spectra revealed spikes in phosphorylation activity within minutes after the addition of the nerve growth factor, in concert with changes in the ratios of such important chemical contents of the cell as proteins, carbohydrates, and lipids. Phosphorylation subsequently waned, then picked up again in another burst of activity on Day 3, just as the cells began to extend neurites.
By comparing results with quantum chemistry simulations by Berkeley Lab's Zhao Hao ? predicting what should be observed from first principles ? as well as with results from partial studies using other methods, the researchers confirmed the monitoring of phosphorylation phases, their timing, and their target proteins, along with associated changes in other substances in the cell.
A new technique takes off
"This experiment was a proof of the concept," says Liang Chen. "We demonstrated the dynamics of protein phosphorylation in controlling differentiation in this biological system using synchrotron infrared spectromicroscopy, and we pointed the way to answering the many questions a biologist has to ask about measuring the coordination of specific processes in real time."
Although in this first experiment the team was not able to follow individual cells continuously, they were able to monitor differentiation in groups of cultured PC12 cells in real time, without labeling or any other invasive procedure. It was the first step in an ambitious inquiry into the real-time biochemistry of living mammalian cells over the long term.
At beamline 1.4.3., with the help of new team members Kevin Loutherback and Rafael Gomez-Sjoberg, the team is designing equipment to maintain mammalian cells in a thin layer of culture media that will keep them healthy yet not interfere with the infrared beam, while automatically monitoring and adjusting temperature, humidity, and nutrient ratios, and removing waste products. This will allow data on individual cells to be gathered continuously throughout the entire phosphorylation process.
Meanwhile the Berkeley Synchrotron Infrared Structural Biology program at ALS beamline 5.4 is building multimodal facilities that will monitor cell development in human cells, bacteria, and plants, within soils, minerals, and other environments, via "hyperspectromicroscopy" ? from the ultraviolet through visible light and deep into the infrared. Researchers will be able to choose the frequency window (or combination of windows) best suited to the sample and the conditions ? in Holman's words, "to watch almost everything at once."
Says Holman, "Many researchers from the medical communities are interested in using the technology, and we are particularly interested in collaborating with university centers and private firms that are seeking a broad view of how promising drugs act within specific cells."
Some of the projects will target Alzheimer's disease, macular degeneration of the retina in diabetes, and mitochondrial diseases in children. In addition, specific processes like protein glycation can also be identified. Since different cells and different organisms respond differently, the eventual goal is to develop specific ways to screen the mechanisms of individual medicines.
###
DOE/Lawrence Berkeley National Laboratory: http://www.lbl.gov
Thanks to DOE/Lawrence Berkeley National Laboratory for this article.
This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.
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Tuesday, May 1, 2012
Income pops in March, but spending rises modestly
Americans' incomes rose by the most in three months in March, but they saved more and spent less, raising further concerns about the recovery.
Personal income increased by 0.4 percent in March, the Commerce Department reported Monday, versus economists' expectations of a 0.3 percent rise.?Spending?rose 0.3 percent, just below forecasts of a 0.4 percent gain.
U.S. economic growth cooled in the first quarter as businesses cut back on investment and restocked shelves at a slower pace.
Stronger consumer spending over the entire quarter cushioned the blow, but Monday's data suggested consumers ended the quarter spending less freely.
With consumption rising less quickly than income, the saving rate edged higher to 3.8 percent.
A price index for personal spending rose 0.2 percent in March. In the 12 months through March, the PCE index was up 2.1 percent, the lowest in a year but still just above the U.S. Federal Reserve's target of 2 percent.?
Reuters contributed to this report.
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George Satula's TEC Blog: Seven Keys to Business Innovation: How ...
Peter Diamandis, founder of the X-Prize Foundation, is the very definition of a change agent. His foundation organizes high-profile contests designed to spur technology development around what he calls ?humanity?s grand challenges?. The initial X-Prize was a $10 million purse famously awarded in 2004 for the first private spacecraft to reach the edge of space twice in two weeks.
Possessed of inspired vision, unflagging energy, and a dedication to leadership, he has been responsible for more real-world innovation than most people dream of in a lifetime.? According to Diamandis, ?If you?re an entrepreneur, it?s about making it happen through the force of your will and vision.?
? Incentivize the change you want to see: Prizes offer an extraordinarily efficient incentive system. This is what drove Lindbergh to cross the Atlantic. Within your own organization, you can create a framework that will drive people to work toward your priorities. The incentive doesn?t need to be large.
? Tolerate failure: People don?t like to take risks, but breakthroughs require people to step outside their comfort zone. Your organization must encourage crazy ideas with no risk to the thinker?s reputation, compensation, or opportunities. Fail early, fail often. If something works, do more of it. This is one of the keys to Silicon Valley?s extraordinary success.
? Attract the best and the brightest: The Internet, social networking, and mobile communications put the talent of the world at your fingertips. There?s no reason why you can?t have set the best talent in the world to work on your problem. Open-source collaboration and crowdsourcing are potent tools.
? Establish constraints: Any creative process requires [certain] boundaries. Otherwise, people do things in the habitual way. Set tight limits on the innovative process ? time, money, materials ? and you?ll force people to think outside the box [and only utilize available resources ? think about the near tragedy of Apollo 13, which was averted through creative thinking and some ?duct tape?].
? Establish credibility: People are skeptical of radical change, so you need to make the change you seek as credible as possible. When the first X-Prize was announced, neither prize money nor contestants existed. But at its debut, on a highly public stage, 20 astronauts, the head of NASA, and members of the Lindbergh family, were present in its support. No one asked where the money would come from or who would compete.
? Leverage your investment: Create a structure that encourages potential innovators [and strategic alliance partners] to spend more than you can invest yourself.
? Encourage youth: Young people don?t have fixed ideas of what?s possible and, more to the point, what?s not. You need an attitude that anything can happen. The engineers who put Apollo on the moon were in their 20s. So were the entrepreneurs who created the dot-com revolution. Make sure your organization allows young people to lead the way to the future.
Excerpted article from Forbes.
Possessed of inspired vision, unflagging energy, and a dedication to leadership, he has been responsible for more real-world innovation than most people dream of in a lifetime.? According to Diamandis, ?If you?re an entrepreneur, it?s about making it happen through the force of your will and vision.?
Move up Move dHere, then, are Diamandis? top principles for innovation-minded companies:
? Incentivize the change you want to see: Prizes offer an extraordinarily efficient incentive system. This is what drove Lindbergh to cross the Atlantic. Within your own organization, you can create a framework that will drive people to work toward your priorities. The incentive doesn?t need to be large.
? Tolerate failure: People don?t like to take risks, but breakthroughs require people to step outside their comfort zone. Your organization must encourage crazy ideas with no risk to the thinker?s reputation, compensation, or opportunities. Fail early, fail often. If something works, do more of it. This is one of the keys to Silicon Valley?s extraordinary success.
? Attract the best and the brightest: The Internet, social networking, and mobile communications put the talent of the world at your fingertips. There?s no reason why you can?t have set the best talent in the world to work on your problem. Open-source collaboration and crowdsourcing are potent tools.
? Establish constraints: Any creative process requires [certain] boundaries. Otherwise, people do things in the habitual way. Set tight limits on the innovative process ? time, money, materials ? and you?ll force people to think outside the box [and only utilize available resources ? think about the near tragedy of Apollo 13, which was averted through creative thinking and some ?duct tape?].
? Establish credibility: People are skeptical of radical change, so you need to make the change you seek as credible as possible. When the first X-Prize was announced, neither prize money nor contestants existed. But at its debut, on a highly public stage, 20 astronauts, the head of NASA, and members of the Lindbergh family, were present in its support. No one asked where the money would come from or who would compete.
? Leverage your investment: Create a structure that encourages potential innovators [and strategic alliance partners] to spend more than you can invest yourself.
? Encourage youth: Young people don?t have fixed ideas of what?s possible and, more to the point, what?s not. You need an attitude that anything can happen. The engineers who put Apollo on the moon were in their 20s. So were the entrepreneurs who created the dot-com revolution. Make sure your organization allows young people to lead the way to the future.
Excerpted article from Forbes.
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